Monday, September 18, 2017: Pamela P. Lackey – President, AT&T South Carolina

Please join us on Monday, September 18th when we will welcome Pamela P. Lackey – President, AT&T South Carolina to our podium.

Pamela P. Lackey is President, AT&T South Carolina, a position she has held since 2007. She is responsible for the public policy, economic development and community affairs activities of AT&T, the premier integrated communications company in the world. In her role, she works closely with state and community leaders to help bring new technology and jobs to the state and improve the quality of life for all South Carolinians.

Ms. Lackey is extensively engaged in community and civic affairs through leadership roles with numerous local and state organizations. She is currently a co-chair of the Transform SC education initiative, a Past Chair of the SC State Chamber Of Commerce, the Chair of the S.C. Ports Authority Board, having been appointed by former Governor Haley and originally confirmed by the State Senate in 2011. The boards on which she serves include the Business Partnership Foundation at USC’s Moore School of Business, the Palmetto AgriBusiness Council, Hollings Cancer Center Advisory Board, and the International African American Museum Board.  She is the 1st female Chair of the Palmetto Business Forum.

Monday, September 11, 2017: Jay Richardson – Assistant US Attorney and Deputy Criminal Chief

Please join us on Monday, September 11th when we will welcome Jay Richardson – Assistant US Attorney and Deputy Criminal Chief to our podium.

Jay grew up in Barnwell, South Carolina before attending Vanderbilt University.  After graduating in 1999 with a Biology degree, Jay moved to Hawaii and worked at a pool-side bar-and-grill.  Jay then earned his JD from University of Chicago Law School, where he served as Articles Editor for the University of Chicago Law Review and right fielder for the law school’s championship softball team.  Following law school, Jay served as law clerk for Seventh Circuit Court of Appeals Judge Richard A. Posner and US Supreme Court Chief Justice William H. Rehnquist. He then practiced with Kellogg, Huber, Hansen in Washington, DC, representing a variety of companies in contract, fraud, intellectual property, and antitrust disputes. Jay returned to South Carolina in 2009 to prosecute gangs, violent criminals, and narcotics traffickers as an Assistant United States Attorney. He is currently the US Attorney’s Deputy Criminal Chief, focusing on white-collar financial crimes and public corruption.  He recently served as lead prosecutor in obtaining the death penalty for Dylann Storm Roof as a result of his attack on parishioners at the Charleston Emanuel AME Church.

 More importantly, he is married to Macon and blessed with four girls. They are active members of Trinity Cathedral and involved at Heathwood Hall.

Monday, August 28, 2017: Congressman Ralph Norman, who won the recent special election for SC’s 5th congressional district

Please join us on Monday, August 28th when we will welcome Congressman Ralph Norman, who won the recent special election for SC’s 5th congressional district to our podium.

Ralph Norman is a lifelong resident of South Carolina’s 5th district. He studied at Rock Hill public schools, graduating from Rock Hill High School in 1971. He attended Presbyterian College in Clinton, SC, and graduated in 1975 with a Bachelor of Science degree in Business.

Ralph has established himself as one of South Carolina’s leading businessmen. He joined his father’s property and construction business right after college, and grew it into one of South Carolina’s most successful commercial real estate developers.

Over the course of his career, Ralph has served with a number of organizations dedicated to improving the community. These organizations include the York County Home Builders Association, the Children’s Attention Home, the Salvation Army, and the Medical University of South Carolina Board of Visitors.

He has consistently demonstrated his dedication to conservative principles. In his 10 years in the South Carolina House of Representatives, Ralph consistently voted in favor of limited government, financially sound policies, and a strong national defense.

Ralph has been Married for 42 years to Elaine Rice Norman. Elaine also is a lifelong resident of South Carolina, growing up in Belton. Together, they have 4 children: Ralph Warren, Anne, Mary Catherine, and Caroline, and 15 grandchildren.

CART FACTS – Tong Li | CART Fund 2017 Grant

Posted by Barbara Ivey, CART Operations VP on May 1, 2017

Research Project: Determining the contributions of age and neuroinflammation on the pathological conversion of Tau

The CART Fund will award Tong Li, Ph.D., Johns Hopkins University School of Medicine, a 2017 research grant in the amount of $75,000. The grant will be awarded on May 9, 2017 at the Annual meeting of The CART Fund in Columbia, SC.

Alzheimer’s disease (AD), the most common form of dementia and a devastating illness for the elderly, is characterized by built-up of clumped proteins observed inside (called tau aggregates) and outside (called amyloid-beta (Aβ) plaques) of nerve cells that lead to memory problems and eventual loss of these cells. Past and current efforts have been focused on finding drugs that could treat either the amyloid or tau problem. Figuring out how these two types of clumped proteins worked together to cause nerve cells to die may hold the key towards finding a solution for AD.

Recently, we established a new mouse model of AD that exhibits accelerated loss of nerve cells due to the built up of clumps of both Aβ and tau. This new mouse model will be valuable for further studying the basis of AD and for screening of drugs that can provide effective therapies for AD. Using this mouse model, we showed that Aβ plaques (outside of nerve cells) facilitate the aggregation of the tau (inside of nerve cells). However, our results indicate that Aβ plaque alone is not sufficient for the built up of tau aggregates. A second risk factor (such as, expression of a fragment of human tau protein) is required to drive the built-up of tau aggregates. Thus, we envision that a combination of risk factors facilitates built-up of tau to drive loss of nerve cells in AD, an idea that can be tested directly in our novel mouse model.

We consider age and inflammation as potential risk factors that drive the built-up of tau aggregates. Among the known risk factors of AD, age is the greatest risk factor and a fundamental driver for development of the disease. AD is also characterized by an inflammatory response. Therefore, we hypothesize that age and inflammatory response facilitate the built-up of tau aggregates to drive nerve cell loss and cognitive decline in AD. We will test this hypothesis using our new mouse model. Resolution of these questions will impact our view regarding disease mechanisms and identification of targets for novel therapeutic strategies for AD.

The Coins for Alzheimer’s Research Trust Fund (CART) is a project of the Rotary Clubs of North America. Founded in 1995 in Sumter SC, CART provides financial support for Alzheimer’s research projects that are yet to be supported by extensive preliminary data but have the potential to substantially advance biomedical research. Learn more at www.cartfund.org